The modulation of the gut microbiome has been widely suggested as a promising therapeutic strategy for inflammatory bowel disease (IBD).Here, we established a novel probiotic cocktail to investigate its therapeutic role in acute colitis mice.During dextran sulfate sodium (DSS)-induced colitis, the mice were treated with the probiotic cocktail, feca
The small ubiquitin-related modifier (SUMOylation) system is a conserved, reversible, post-translational protein modification pathway covalently attached to the lysine residues of proteins in eukaryotic cells, and SUMOylation read more is catalyzed by SUMO-specific activating enzyme (E1), binding enzyme (E2) and ligase (E3).Sentrin-specific proteas
Immunomodulatory duospiritalis.com therapies have fueled interest in targeting microglial cells as part of the innate immune response after infection or injury.In this context, the colony-stimulating factor 1 (CSF-1) and its receptor (CSF-1R) have gained attention in various neurological conditions to deplete and reprogram the microglia/macrophages
Locked-in syndrome (LIS) is a rare diagnosis in which patients present with quadriplegia, lower cranial nerve paralysis, and mutism.It is clinically difficult to differentiate from other similarly presenting diagnoses with no standard approach for assessing such poorly responsive patients.The purpose of this case is to highlight the clinical differ